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Diet and Nutrition as an Anti-Cancer Strategy See also Specific anti-cancer Proven Products See also the American Cancer Institute Nutritional or dietary factors are attracting a great deal of interest because of their perceived ability to act as highly effective chemopreventive agents. They are perceived as being generally safe and may have efficacy as chemopreventive agents by preventing or reversing premalignant lesions and or reducing second primary tumor incidence. Many of these compounds appear to act on multiple tumor promoter-stimulated cellular pathways. Some of the most interesting products are resveratrol and components of tea like EGCG, theafavins and even caffeine. Other potentially effective dietary compounds include perillyl alcohol, PEITC, giner and CAPE. Many of these compounds act by effecting multiple target signaling pathways including inducing apoptosis and/or suppressing AP-1, NF-қB and/or XOX-2 expression. The search for natural products with anti-inflammatory, immunomodulatory or antineoplatic potential is an important issue in drug discovery. There is great interest in drugs involving new targets to treat inflammatory, autoimmune, or cancer-related diseases. It has been surmised that the search for compounds that inhibit transcription factors, such as nuclear factor (NF)-κB or activated protein-1 (AP-1), should be a good approach for finding new lead compounds with anti-inflammatory potential. Among the products shown to inhibit NF-κB are the following:
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