Drug Development

Tools and approaches of genomics and proteomics are having a major impact on drug discovery and development including target identification and verification and high throughput screening of potential drugs. For example, cell microarrays can be used to screen for gene products involved in biological processes of pharmaceutical interest and as in situ protein microarrays for development and assessment of lead compounds. Activity-based/chemical proteomics can also be used to covalently modify a set of related enzymes and facilitate their purification and or identification as potential drug targets.

Yeast is a powerful model organisms to identify genes involved in drug responses. A yeast deletion collection which consists of about 21,000 hapliod strains and heterozygous and homozygous diploid strains of S. cerevisiae that each possess a precise deletion (from the start to the stop codon) in one of about 6000 yeast genes has been generated. In any experimental screen this collection of about 6000 genomes can be assayed and all genes required for growth can be identified.

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